Lymphatic filariasis is one of the neglected diseases; however its elimination appears not only feasible if programmes are sustained over a 5-year time scale but the programme has unique characteristics which enable it to appeal to a wide constituency of donors (Tables 2 and 5).Lymphatic filariasis elimination can viably contribute to the achievement of the Millennium Development Goals. Lymphatic filariasis is one of the most debilitating neglected tropical diseases, the clinical manifestations of which include painful and incapacitating lymphoedema.1 Among the estimated 68 million people infected, 36 million are microfilaria carriers and 40 million are symptomatic.1 Additionally, 946 million people live in areas of southeast Asia and sub-Saharan Africa where mosquito-borne. Introduction. Lymphatic filariasis is a parasitic infection caused by the filarial nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori. 1 These parasites are transmitted by members of several mosquito genera, particularly Anopheles, Aedes, Culex, and Mansonia, with geographic variation in the identity of dominant vectors. 2 Long-term infection can cause deterioration of the.
Google Scholar 5. WHO (2007) Global Programme to Eliminate Lympathic Filariasis. Wkly Epidemiol Rec 82: 361-380. View Article Google Scholar 6. Raccurt C, Hodges W, Boncy J (1983) [Lymphatic filariasis in Haiti. Results of treatment with diethylcarbamazine in the town of Limbe] In 2020, our web migration project tackled over 180,000 pages of content and over 200,000 publications. Much of our content has been updated, made more dynamic and may no longer be found in the same place. If you are having problems finding content, please try: Search for publications in our new Publications Hub. Find content in Health Topics
Filariasis is a major social health problem in tropical countries like India. Wuchereria bancrofti accounts for 95% cases of lymphatic filariasis. The adult worm resides in the lymphatics and lymph nodes and causes little inflammatory response as long as it is alive, but granulomatous reaction is noted once the death of parasite occurs Appawu MA, Dadzie SK, Wilmot-Baffoe A, Wilson MD (2001) Lymphatic Filariasis in Ghana: Entomological investigation of transmission dynamics and intensity in communities served by irrigation systems in the Upper East Region of Ghana. Trop Med Int Health 6: 511-516. [Google Scholar
. Lymphatic filariasis (LF) is a mosquito-borne filarial disease targeted for elimination by the year 2020. The Republic of Togo undertook mass treatment of entire endemic communities from 2000 to 2009 to eliminate the transmission of the disease and is currently the first sub-Saharan African country to be validated by WHO for the elimination of LF as a public health problem The lymphatic system is fundamentally important to cardiovascular disease, infection and immunity, cancer, and probably obesity — the four major challenges in healthcare in the 21st century. This Review will consider the manner in which new knowledge of lymphatic genes and molecular mechanisms has demonstrated that lymphatic dysfunction. Abstract. A national filariasis survey was conducted to determine the prevalence and distribution of Wuchereria bancrofti microfilaraemia and clinical disease associated with lymphatic filariasis in Ghana. Multi-stage systematic sampling was used to select households to be examined in all 10 administrative regions of the country Lymphatic filariasis (LF) is a major public health problem in the Pacific Region, including in Fiji. Through transmission by the mosquito vector Aedes, Fiji has suffered the burden of remaining endemic with LF despite efforts at elimination prior to 1999. In the year 1999, Fiji agreed to take part in the Pacific Programme for Elimination of LF (PacELF) and the Global Programme to Eliminate LF Shenoy RK, Suma TK, Kumaraswami V, Rahmah N, Dhananjayan G, et al. Preliminary findings from a cross-sectional study on lymphatic filariasis in children, in an area of India endemic for Brugia malayi infection. Ann Trop Med Parasitol. 2007; 101:205-213. [Google Scholar
. 2004). Its distribution extends from Latin America, across central Africa, southern Asia and into the Pacific Islands Introduction. The clinical images of lymphatic filariasis—grossly swollen legs (Figure 1) and enlarged male genitals—have been well known across the world for many years.Prior to the establishment of the global programme to eliminate lymphatic filariasis (GPELF) in 2000, the general understanding of this condition, and its effects on patients and their families, remained largely one of. Symbiotic Wolbachia organisms of filarial nematodes have received much attention as possible chemotherapy targets and disease-causing organisms. In order to further investigate the association between anti-Wolbachia immune responses and chronic filarial disease in humans, antibody responses to Wolbachia surface protein (WSP) were assayed in serum samples collected from 232 individuals living. Introduction. Lymphatic filariasis (LF) is a neglected tropical disease caused by nematode worms that live in the lymphatic vessels of humans. It is caused by three species of filarioid worms (Wuchereria bancrofti, Brugia malayi, and Brugia timori) and transmitted by mosquitoes.In 2012, it is estimated that LF was prevalent in over 83 tropical and subtropical countries globally with 1.2. T-bet (T-box expressed in T cells) and GATA-3 are transcription factors that play a critical role in the development of Th1 and Th2 cells, as do genes of the SOCS (suppressor of cytokine signaling) family, albeit indirectly. Another transcription factor, Foxp3, is a master regulator of natural regulatory T cells (Tregs). To identify the role of these factors in impaired Th1 responses of patent.
Google Scholar. M. Appawu, M. Appawu 1 Noguchi Memorial Institute for Medical Research, University of Ghana, P.O. Box 25, Legon, Ghana. Parasitological, clinical and entomological surveys for lymphatic filariasis were carried out in 6 villages and 3 towns on the coast of Ghana. Few or no filarial infections were observed in the towns or in.
Infection and disease in lymphatic filariasis: an epidemiological approach - Volume 104 Issue S Lymphatic filariasis (LF), already recognized as a widespread, seriously handicapping disease of adults, was generally thought to occur only sporadically in children. New, highly sensitive diagnostic tests (antigen detection, ultrasound examination) now reveal, however, that LF is first acquired in childhood, often with as many as one‐third of children infected before age 5 Lymphatic filariasis is a major infectious disease and public health problem in Papua New Guinea (PNG) and other island nations of the Pacific region. Evidence of the disease in this area of the world was first recorded in the 17th and 18th centuries when Europeans made contact with island communities  Among infections closely associated with poverty, lymphatic filariasis (LF) is a study in contrasts. It is both a consequence of and a contributor to poverty. Although rarely fatal, it is recognized as a leading global cause of lifelong disability as well as significant personal, social, and economic burdens coincident with disease. Infection is often considerably more prevalent in communities. Lymphatic filariasis caused by Wuchereria bancrofti and Brugia malayi is endemic throughout most of the southern half of the Philippine archipelago. Economic and manpower shortages prior to 1996 made it difficult to acquire new prevalence data and vector control data concurrently from all provinces. Nevertheless, analysis of cumulative prevalence data on filariasis indicates the persistence of.
Introduction. Lymphatic filariasis (LF) is a disabling, neglected tropical disease (NTD), transmitted to humans by mosquitos, that has plagued societies for millennia. 1 The historical burden of LF has been widespread; in 2000, suspected transmission was ongoing in 80 countries, with an estimated 1.34 billion people at risk for infection and 120 million people infected. 2 However, a turning. Progress and Impact of 13 Years of the Global Programme to Eliminate Lymphatic Filariasis on Reducing the Burden of Filarial Disease. PLoS Negl Trop Dis 2014; 8:e3319 10.1371/journal.pntd.0003319 [PMC free article] [Google Scholar Hoerauf A (2008) Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis. Curr Opin Infect Dis 21:673-681 Google Scholar Hoerauf A, Volkmann L, Hamelmann C, Adjei O, Autenrieth IB, Fleischer B, Buttner DW (2000a) Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis
The present study describes the current standings of potent antifilarial compounds against lymphatic filariasis. Methods: A literature search was conducted for naturally occurring and synthetic antifilarial compounds by referencing textbooks and scientific databases (SciFinder, PubMed, Science Direct, Wiley, ACS, SciELO, Google Scholar, and. Lymphatic filariasis (LF) is an important neglected parasitic disease according to the World Health Organization. In this study, we aimed to determine the prevalence of human LF in Asia using a systematic review and meta-analysis approach. Records from 1990 to 2018 in reputable databases including PubMed, Science Direct, Embase, and Cochrane Library were searched using a panel of related keywords In the global drive for elimination of lymphatic filariasis (LF), 15 countries have achieved validation of elimination as a public health problem (EPHP). Recent empirical evidence has demonstrated that EPHP does not always lead to elimination of transmission (EOT). Here we show how the probability of elimination explicitly depends on key biological parameters, many of which have been poorly.
Search Google Scholar; Export Citation; 2. Gyapong JO, Kumaraswami V, Biswas G, Ottesen EA, 2005. Treatment strategies underpinning the global programme to eliminate lymphatic filariasis. A widely recognized secondary benefit of MDA for lymphatic filariasis is the likely health benefit that would accrue from the reduction of the burden of. Al-Kubati AS, Al-Samie AR, Al-Kubati S, Ramzy RMR. The story of lymphatic filariasis elimination as a public health problem from Yemen. Acta Trop. 2020; 212:105676. doi: 10.1016/j.actatropica.2020.105676. [Google Scholar
Frequency distribution of lymphatic filariasis microfilariae in human populations: population processes and statistical estimation - Volume 101 Issue 3. Skip to main content Accessibility help Google Scholar Citations. View all Google Scholar citations for this article Google Scholar 19. Sinha P, Matthay M, Calfee C. Is a Cytokine Storm Relevant to COVID-19? JAMA Intern Med. 2020;180:1152-1154. pmid:32602883 . View Article PubMed/NCBI Google Scholar 20. Goel TC, Goel A, Goel TC, Goel A. Eosinophilia in Lymphatic Filariasis World Health Organization. Global programme to eliminate lymphatic filariasis: Progress Report 2018. Wkly Epidemiol Rec. 2019;94(41): 457-47. View Article Google Scholar 7. Michael E, Bundy DAP. Global mapping of lymphatic filariasis. Trends in Parasitology. 1997;13(12):472-476. pmid:1527513
Die Parasiten des Menschen und die von ihnen herrührenden Ein Hand- und Lehrbuch für Naturforscher und Aertze (The parasites of man and the diseases which proceed from them. A textbook for students and practitioners, translated by W.E. Hoyle and J. Young). Vol. 1. Pentland, Edinburgh, Scotland. 1009 pp. Google Scholar Talbot JT, Vial A, Direny A, de Rochars MB, Addiss D, et al. Predictors of compliance in mass drug administration for the treatment and prevention of lymphatic filariasis in Leogane, Haiti. Am J Trop Med Hyg. 2008; 78:283-288. [Google Scholar Onchocerciasis and lymphatic filariasis (LF) are endemic in Mali , but large-scale interventions have progressed toward elimination of transmission (EOT) for onchocerciasis and elimination as a public health problem (EPHP) for LF.The Onchocerciasis Control Programme in West Africa (OCP) began vector control in Mali in 1977, identifying and larviciding Simulium (black fly) breeding sites  Guyana For Specific Travellers: Lymphatic Filariasis [risk] Risk of Lymphatic filariasis is present in Guyana. [/risk] Description. Lymphatic Filariasis, also known as Elephantiasis, is a parasitic infection caused by the Wuchereria bancrofti, B rugia malayi, and Brugia timori nematode worms transmitted to humans through the bite of infected Aedes, Culex, Anopheles, and Mansonia mosquitoes
Crossref, Medline, Google Scholar; 15. Ramaiah KD, Ottesen EA. Progress and impact of 13 years of the global programme to eliminate lymphatic filariasis on reducing the burden of filarial disease. PLoS Negl Trop Dis 2014; 8:e3319. Crossref, Medline, Google Scholar; 16. Fu MR To investigate the consequences of the impaired parasite-specific immune response in lymphatic filariasis, the effect of concurrent Wuchereria bancrofti infection on the immune response to tetanus toxoid (TT) following tetanus vaccination was studied in 20 asymptomatic microfilaremic (MF) patients, 20 patients with chronic lymphatic obstruction. World Health Organization: Global programme to eliminate lymphatic filariasis. progress report on mass drug administrations in 2007. Wkly Epidemiol Rec. 2008, 83 (37): 333-348. Google Scholar 2. World Health Organization: Global programme to eliminate lymphatic filariasis: progress report on mass drug administration, 2010 Shrinking the lymphatic filariasis map: update on diagnostic tools for mapping and transmission monitoring - Volume 141 Issue 1 Babu BV, Acharya AS, Mallick G, et al. Lymphatic filariasis in Khurda district of Orrisa, India: An epidemological study. SE Asian J Trop Med Public Health. 2001;32(2):240-3. Google Scholar
An epidemiological model for the spread of lymphatic filariasis, a mosquito-borne infection, is developed and analysed. The epidemic thresholds known as the reproduction number and equilibria for the model are determined and stabilities analysed. Results from the analysis of the reproduction number suggest that treatment will somehow contribute to a reduction in lymphatic filariasis cases, but. Google Scholar; The use of ivermectin will expand. For example, findings showed that ivermectin combined with diethylcarbamazine and albendazole is more effective than diethylcarbamazine plus albendazole as part of an MDA campaign for the treatment of lymphatic filariasis, resulting in greatly expanded use of ivermectin in MDA programmes. Article PubMed Google Scholar 2. Ravindran B: Aping Jane Goodall: insights into human lymphatic filariasis. Trends Parasitol. 2003, 19: 105-109. 10.1016/S1471-4922(03)00004-7. Article PubMed Google Scholar 3. Ottesen EA: The global programme to eliminate lymphatic filariasis
World Health Organization. Global programme to eliminate lymphatic filariasis: progress report, 2019. Wkly Epidemiol Rec. 2020;95(43):509-24. Google Scholar 7. World Health Organization. Global programme to eliminate lymphatic filariasis: progress report, 2016. Wkly Epidemiol Rec. 2017;92(40):594-608 Global Programme to Eliminate Lymphatic Filariasis: Progress report 2004. Wkly Epidemiol Record. 2005;80:201-12. Google Scholar 76. WHO/Department of Control of Neglected Tropical Diseases Global Programme to Eliminate Lymphatic Filariasis: Progress report on mass drug administration in 2008. Wkly Epidemiol Rec. 2009;42:437-44. 77 The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was launched in 2000 with the primary objective of interrupting parasite transmission and relieving suffering associated with the disabling symptoms 6, 15. Article Download PDF View Record in Scopus Google Scholar. 11. D.H. Molyneux, et al Lymphatic filariasis (LF) is a major cause of acute and chronic morbidity manifested as lymphedema and hydrocele. The clinical signs and symptoms of LF affect more than 40 million people globally, making the disease the second-largest cause of permanent and long-term disability worldwide (Shenoy and Bockarie, 2011, Chu et al., 2010) Sub-Saharan Africa (SSA) carries nearly one-third of the global burden of lymphatic filariasis (LF), a vector-borne and debilitating disease that afflicts the poorest population. Wuchereria bancrofti is the only species responsible for the disease and is mainly transmitted to humans by mosquito species belonging to Anopheles and Culex. The disease is estimated to be transmitted in 37 out of.
Google Scholar]. The need for pre-treatment of serum by boiling, the long incubation times required for the slow-binding IgM, and a three-step detection and indicator system means that the assay is cumbersome by standards of today. An important factor in the long-term success of the global program to eliminate lymphatic filariasis is the. Defining a prevalence level to describe the elimination of Lymphatic Filariasis (LF) transmission and designing monitoring & evaluating (M&E) programs post the cessation of mass drug administration (MDA). PLoS Negl Trop Dis 2020; 14:e0008644. [Europe PMC free article] [Google Scholar Lymphatic filariasis (LF) is a tropical disease caused by infection with the parasitic filarial worms: Wuchereria bancrofti, Brugia malayi, and Brugia timori. The symptoms of this chronic disease appear in adults (in men more than in women) and include damage to the lymphatic system, arms, legs, and genitals, which cause significant pain, reducing productivity, and social problems Lymphatic filariasis: a handbook of practical entomology for national lymphatic filariasis elimination programmes. Geneva, Switzerland: World Health Organization, 2013. Report No.: 9241505648. [Google Scholar
CAS PubMed PubMed Central Google Scholar 3. Ottesen EA (2000) The global programme to eliminate lymphatic filariasis. Trop Med Int Hlth. 2000; 5: 591-594. 4. WHO/WPRO. The PacELF way: towards elimination of lymphatic filariasis from the Pacific, 1999-2005. 2006. Google Scholar 5 Triteeraprapab S, Karnjanopas K, Porksakorn C, Sai-Ngam A, Yentakam S, Loymak S (2001) Lymphatic filariasis caused by Brugia malayi in an endemic area of Narathiwat Province, southern of Thailand. J Med Assoc Thail 84(Suppl 1):S182-S188 Google Scholar . It is an important cause of physical and social disability that affects over 100 million people in 83 countries in the developing world. Google Scholar]. With a target population of 1.3. Lymphatic Filariasis (LF), a parasitic nematode infection, poses a huge economic burden to affected countries. LF endemicity is localized and its prevalence is spatially heterogeneous. In Ghana, there exists differences in LF prevalence and multiplicity of symptoms in the country's northern and southern parts. Species distribution models (SDMs) have been utilized to explore the suite of risk. Background and Objectives: Lymphatic filariasis is a neglected tropical disease caused by infection with filarial worms that are transmitted through mosquito bites. Globally, 120 million people are infected, with nearly 40 million people disfigured and disabled by complications such as severe swelling of the legs (elephantiasis) or scrotum.
. Ann Trop Med Parasitol. 2000;94(4):353-64. CAS Article PubMed Google Scholar 28. Ramaiah KD, Das PK, Michael E, Guyatt H. The economic burden of lymphatic filariasis in India. Parasitol Today. 2000;16(6):251-3 This detailed review of the published studies underlying ivermectin's recent registration for use in lymphatic filariasis (LF) demonstrates the drug's single-dose efficacy (over the range of 20-400μg/kg) in clearing microfilaraemia associated with both Wuchereria bancrofti and Brugia malayi infections of humans. While doses as low as 20μg/kg could effect transient microfilarial (mf. World Health Organization, Lymphatic filariasis: the disease and its control, Fifth Report of The WHO Expert Committee on Filariasis, Geneva, Switzerland, 1992. View at: Google Scholar P. Rosenblatt, P. C. Beaver, and T. C. Orihel, A filarial infection apparently acquired in New York City, The American Journal of Tropical Medicine.
The Global Program to Eliminate Lymphatic Filariasis (GPELF) Google Scholar. 3. King CL, Suamani J, Sanuku N, et al. A trial of a triple-drug treatment for lymphatic filariasis Author summary Lymphatic filariasis (LF) is a deforming and disabling infectious disease manifested in the form of elephantiasis and hydroceles. Based on mapping data, 61 out of 75 districts of Nepal were found to be endemic for LF and mass drug administration (MDA) of diethylcarbamazine and albendazole has been already started in 56 districts
Lymphatic filariasis is a particularly interesting case in point. This parasitic infection, one of six diseases considered potentially eliminable, was endorsed for global elimination as a public health problem by the World Health Assembly in 1997 and a global elimination programme, using annual mass drug administration, was established in 2000. Google Scholar Dreyer G. , Medeiros Z. , Netto MJ , Leal NC , de Castro LG , Piessens WF Acute attacks in the extremities of persons living in an area endemic for bancroftian filariasis: differentiation of two syndromes Mass drug administration trial to eliminate lymphatic filariasis in Papua New Guinea: changes in microfilaremia, filarial antigen, and Bm14 antibody after cessation. Am J Trop Med Hyg 78:289-293. Google Scholar Lymphatic filariasis, which was endemic in 81 countries by the turn of the new millennium, was a neglected disease in the developing world, until it was recognized as the leading cause of physical disability worldwide. 50, 51 Hence, in 2000, the WHO started a global eradication campaign to eliminate filariasis Introduction. In men, scrotal hydrocele is the most common chronic clinical manifestation of bancroftian filariasis ( Wijers 1977; Gyapong et al. 1994 ).The pathogenesis of hydrocele associated with lymphatic filariasis remains obscure ( Ottesen 1992), but the high frequency of urogenital disease in men with bancroftian filariasis is almost certainly related to the apparent preference of adult.
A systematic search in Ovid MEDLINE and Google Scholar were conducted. Relevant synonyms for the Medical Subject Headings (MeSH) terms lymphatic filariasis were used to compile an initial list of articles. Relevant articles were isolated after reviewing abstracts. Articles not written in English were excluded Mathematical models and lymphatic filariasis control: endpoints and optimal interventions. Trends Parasitol. 2006;22:226-33. Article Google Scholar 4. World Health Organization. Monitoring and Epidemiological Assessment of Mass Drug Administration for the Global Programme to Eliminate Lymphatic Filariasis (GPELF) Progress and impact of 13 years of the global programme to eliminate lymphatic filariasis on reducing the burden of filarial disease. PLOS Neglected Tropical Diseases 2014; 8:e3319. 10.1371/journal.pntd.0003319 [Europe PMC free article] [Google Scholar Objective To determine the economic loss in terms of treatment costs and loss of productive time because of acute episodes of adenolymphangitis (ADL) caused by lymphatic filariasis (LF) in a rural population of coastal Orissa, India. Methods Data on expenditure on treatment and loss of work along with other epidemiological information were collected through a 1‐year surveillance of 113 acute. Lymphatic Filariasis, also known as elephantiasis, is a neglected tropical disease causing chronic damage to the lymphatic system. The disease, due to its peculiar morphological manifestations and disfigurations, is associated with severe social stigma and results in severe economic and mental stress for the affected. India's National Health Policy (2002) was aiming at the elimination of.
The Global Programme to Eliminate Lymphatic Filariasis has an urgent need for rapid assays to detect ongoing transmission of lymphatic filariasis (LF) following multiple rounds of mass drug administration (MDA). Current WHO guidelines support using the antigen card immunochromatographic test (ICT), which detects active filarial infection but does not detect early exposure to LF. Recent studies. Background: Understanding factors surrounding the implementation process of mass drug administration for lymphatic filariasis (MDA for LF) elimination programmes is critical for successful implementation of similar interventions. The sub-Saharan Africa (SSA) region records the second highest prevalence of the disease and subsequently several countries have initiated and implemented MDA for LF Modi A, Gamit S, Jesalpura BS, Kurien G, Kosambiya JK. Reaching endpoints for lymphatic filariasis elimination—results from mass drug administration and nocturnal blood surveys, South Gujarat, India. PLoS Negl Trop Dis. 2017; 11 (4):e0005476. doi: 10.1371/journal.pntd.0005476. [Europe PMC free article] [Google Scholar We conclude that in lymphatic filariasis, the clinical response to a single dose of ivermectin compares favorably with that after the standard 12-day course of diethylcarbamazine Salt fortified with diethylcarbamazine (DEC) as an effective intervention for lymphatic filariasis, with lessons learned from salt iodization programmes - Volume 121 Issue S1. Skip to main content Accessibility help Google Scholar Citations. View all Google Scholar citations for this article